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Related post: INSTITUTE AND LOCATION
NIAID, NIH, Bethesda, MD 20205
TOTAL MAN-YEARS:
2.7
PROFESSIONAL:
1.7
OTHER:
1.0
CHECK APPROPRIATE BOX(ES)
D (a) Human subjects
D (a1) Minors
n (a2) Interviews
D (b) Human tissues S (c) Neither
SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided.)
We have constructed an operational epitope map Minocin Cost of the type 3 parainfluenza
virus (PIV3) hemagglutinin-neuraminidase (HN) protein. Neutralizing monoclonal
antibodies (mAbs) specific for the HN protein were used to select
antibody-resistant antigenic variants. Reactivity patterns of the mAbs with the
antigenic variants and with human clinical strains have identified 11 unique HN
epitopes. Five of these epitopes vary antigenically in clinical strains whereas
variation in six other epitopes is extremely rare. Competitive-binding
radioimmunoassays indicated Minocin Price that the 11 epitopes are located in two topologically
distinct antigenic sites on the HN molecule.
The antigenic variants achieve maximum levels of replication in cotton rat
lungs and nasal turbinates which are not significantly different from that achieved
by wild type PIV3, indicating that the HN molecule can accomodate antigenic
alterations without loss of function. Passive transfer of individual mAbs that
neutralize virus in vitro causes a 10-100 fold reduction in viral replication in
cotton rat lungs after challenge with wild-type virus, whereas transfer of a
mixture of six mAbs reduces virus replication to an undetectable level.
Nucleotide sequence analysis of the antigenic variants is being performed to
construct a molecular epitope map of the HN protein. Comparison of the HN gene
sequences of three variants to that of the wild type virus identified a single
point mutation in each of the variant HN genes. These mutations code for a single
amino acid substitution in the HN protein Purchase Minocin which is responsible for loss of
antibody-binding .
7-54
PHS 6040 (Rev. 1/84)
GPO ai4-»is
DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT
PROJECT NUMBER
ZOl AI 00344-04 LID
PERIOD COVERED
October 1, 1984 to September 30, 1985
TITLE OF PROJECT (80 characters or less. Title must fit Minocin Mr on one line Minocin Tablets between the borders.)
Immunologic Factors in Respiratory Syncytial Virus (RSV) Disease
PRINCIPAL INVESTIGATOR (List other professional personnel below the Principal Investigator.) (Name, title, laboratory, and institute affiliation)
PI: Gregory A. Prince, D.D.S., Ph.D. Expert LID, NIAID
Others: Robert M. Chanock, M.D.
Brian R. Murphy, M.D.
Chief, LID
Head, RVS, LID
LID, NIAID
LID, NIAID
COOPERATING UNITS (if any)
LAB/BRANCH
Laboratory of Infectious Diseases
SECTION
Respiratory Viruses Section
INSTITUTE AND LOCATION
NIAID, NIH, Bethesda, Maryland 20205
TOTAL MAN-YEARS:
0.95
PROFESSIONAL:
0.45
OTHER:
0.5
CHECK APPROPRIATE BOX(ES)
D (a) Human subjects
D (a1) Minors
D (a2) Interviews
D (b) Human tissues 3 (c) Neither
SUMMARY OF WORK (Use standard unreduced type. Do not exceed the Buy Minocin space provided.)
Cotton rats previously
inoculated with formalin-inactivated RSV Minocin 50mg were challenged intranasally with live RSV
in an attempt to experimentally induce an enhancement of RSV disease similar to
that observed following administration of formalin-inactivated RSV vaccine to
infants 20 years ago. Within 24 hours after infection with RSV cotton rats
developed pulmonary lesions that Minocin Coupon reached a maximum by the fourth day.
Histologically the lesions resembled an experimental pulmonary Arthus reaction,
although adoptive transfer experiments were not successful in confirming Minocin Iv this
mechanism. An action of formalin on Minocin 100 Mg RSV appears to be responsible for this effect,
because live virus or virus heated in the absence of formalin did not induce
enhanced immunopathology. Selected epitopes on the F and/or G RSV surface
glycoproteins Antibiotic Minocin that are involved in inducing neutralizing antibodies were modified
so as to reduce or ablate their antigenicity. Minocycline Minocin However, other epitopes on the F
and/or G glycoproteins are not ablated by formalin Minocin Antibiotic because cotton Buy Minocin Online rats inoculated
parenterally with formalin-inactivated virus developed a high level of F and G
antibodies measurable by ELISA.
At this time the effect of formalin on RSV cannot be localized to either
the F or G glycoprotein of RSV. Although the site(s) at which formalin acts to
produce its disease enhancing effect has not been identified it is clear
formalin-treated RSV stimulates an unbalanced immune Minocin Minocycline response in which an unusually
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