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Related post: INSTITUTE AND LOCATION NIAID, NIH, Bethesda, MD 20205 TOTAL MAN-YEARS: 2.7 PROFESSIONAL: 1.7 OTHER: 1.0 CHECK APPROPRIATE BOX(ES) D (a) Human subjects D (a1) Minors n (a2) Interviews D (b) Human tissues S (c) Neither SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided.) We have constructed an operational epitope map Minocin Cost of the type 3 parainfluenza virus (PIV3) hemagglutinin-neuraminidase (HN) protein. Neutralizing monoclonal antibodies (mAbs) specific for the HN protein were used to select antibody-resistant antigenic variants. Reactivity patterns of the mAbs with the antigenic variants and with human clinical strains have identified 11 unique HN epitopes. Five of these epitopes vary antigenically in clinical strains whereas variation in six other epitopes is extremely rare. Competitive-binding radioimmunoassays indicated Minocin Price that the 11 epitopes are located in two topologically distinct antigenic sites on the HN molecule. The antigenic variants achieve maximum levels of replication in cotton rat lungs and nasal turbinates which are not significantly different from that achieved by wild type PIV3, indicating that the HN molecule can accomodate antigenic alterations without loss of function. Passive transfer of individual mAbs that neutralize virus in vitro causes a 10-100 fold reduction in viral replication in cotton rat lungs after challenge with wild-type virus, whereas transfer of a mixture of six mAbs reduces virus replication to an undetectable level. Nucleotide sequence analysis of the antigenic variants is being performed to construct a molecular epitope map of the HN protein. Comparison of the HN gene sequences of three variants to that of the wild type virus identified a single point mutation in each of the variant HN genes. These mutations code for a single amino acid substitution in the HN protein Purchase Minocin which is responsible for loss of antibody-binding . 7-54 PHS 6040 (Rev. 1/84) GPO ai4-»is DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE NOTICE OF INTRAMURAL RESEARCH PROJECT PROJECT NUMBER ZOl AI 00344-04 LID PERIOD COVERED October 1, 1984 to September 30, 1985 TITLE OF PROJECT (80 characters or less. Title must fit Minocin Mr on one line Minocin Tablets between the borders.) Immunologic Factors in Respiratory Syncytial Virus (RSV) Disease PRINCIPAL INVESTIGATOR (List other professional personnel below the Principal Investigator.) (Name, title, laboratory, and institute affiliation) PI: Gregory A. Prince, D.D.S., Ph.D. Expert LID, NIAID Others: Robert M. Chanock, M.D. Brian R. Murphy, M.D. Chief, LID Head, RVS, LID LID, NIAID LID, NIAID COOPERATING UNITS (if any) LAB/BRANCH Laboratory of Infectious Diseases SECTION Respiratory Viruses Section INSTITUTE AND LOCATION NIAID, NIH, Bethesda, Maryland 20205 TOTAL MAN-YEARS: 0.95 PROFESSIONAL: 0.45 OTHER: 0.5 CHECK APPROPRIATE BOX(ES) D (a) Human subjects D (a1) Minors D (a2) Interviews D (b) Human tissues 3 (c) Neither SUMMARY OF WORK (Use standard unreduced type. Do not exceed the Buy Minocin space provided.) Cotton rats previously inoculated with formalin-inactivated RSV Minocin 50mg were challenged intranasally with live RSV in an attempt to experimentally induce an enhancement of RSV disease similar to that observed following administration of formalin-inactivated RSV vaccine to infants 20 years ago. Within 24 hours after infection with RSV cotton rats developed pulmonary lesions that Minocin Coupon reached a maximum by the fourth day. Histologically the lesions resembled an experimental pulmonary Arthus reaction, although adoptive transfer experiments were not successful in confirming Minocin Iv this mechanism. An action of formalin on Minocin 100 Mg RSV appears to be responsible for this effect, because live virus or virus heated in the absence of formalin did not induce enhanced immunopathology. Selected epitopes on the F and/or G RSV surface glycoproteins Antibiotic Minocin that are involved in inducing neutralizing antibodies were modified so as to reduce or ablate their antigenicity. Minocycline Minocin However, other epitopes on the F and/or G glycoproteins are not ablated by formalin Minocin Antibiotic because cotton Buy Minocin Online rats inoculated parenterally with formalin-inactivated virus developed a high level of F and G antibodies measurable by ELISA. At this time the effect of formalin on RSV cannot be localized to either the F or G glycoprotein of RSV. Although the site(s) at which formalin acts to produce its disease enhancing effect has not been identified it is clear formalin-treated RSV stimulates an unbalanced immune Minocin Minocycline response in which an unusually
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